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Recombinat Lipoprotein-associated phospholipase A2 (Lp-PLA2) Protein, start from 0.1 mg

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$90.00
21231275
In stock
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Minimum quantity for "Recombinat Lipoprotein-associated phospholipase A2 (Lp-PLA2) Protein, start from 0.1 mg" is 1.

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Product Description
 

Human Lp-PLA2 Antigen

Quantity: 0.1 mg

Description:

Gene ID:7941

Alternate Names: LDL-PLA2; LP-PLA2; PAFAD; PAFAF

Lipoprotein-associated phospholipase A2, also known as platelet-activating factor acetyl hydrolase (PAF-AH), is a phospholipase A2enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45-kDaprotein of 441 amino acids. It is one of several PAF acetyl hydrolases. Lp-PLA2is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib). In human atherosclerotic lesions, 2 main sources of Lp-PLA2 can be identified, including that which is brought into the intima bound to LDL (from the circulation), and that which is synthesized de novo by plaque inflammatory cells (macrophages, T cells, mast cells)."

It is used as a marker for cardiac disease.

Formulation: Liquid, supplied in PBS buffer, pH 8.0, containing 0.05%sodium azide.

Applications: Excellent for use as a control or calibrator.

Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.

Certification: n/a.

Source: Human plasma.

Purity: 95%

Concentration:

Fig 1. 1 ug of purified Lp-PLA2 protein on SDS-PAGE gel.

Storage and Stability: Stable at 4°C for shipping purposes and short term storage.

Upon receipt, store at -20°C. After reconstitution, store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.

NOT FOR HUMAN USE. FOR RESEARCH ONLY. NOT FOR THERAPEUTICUSE.

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