Recombinant Human Interferon alpha-inducible protein 27 from E. coli, 100 ug, cat# 21231298
Human interferon alpha-induced protein 27 is a 122 amino acid protein, has has antiviral activity[1,2], prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A (RNA dependent RND polymase, RdRp) and the ubiquitinating machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A.
IFI27 Protein Product Information
Synonym : | IFI27 |
Protein Construction: | A DNA sequence coding 121 amino acid length of IFI27 mature protein was cloned into ApreBioTM vector, and expressed in BL21. |
Source: | Homo sapiens |
Expression Host: | E. coli. |
PCT Protein QC Testing
Purity: | > 90 % as determined by SDS-PAGE | SDS-PAGE:
M, AmeriDx protein marker. 10ug (1), 5ug(2), 2.5ug (3) and 1 ug (4) of Recombinant |
Stability: | Samples are stable for up to twelve months from date of receipt at -70oC/p> | |
Molecular Mass: | 13 kDa on SDS-PAGE gel | |
Formulation: | lyophilized from the protein solution in sterile PBS, pH 7.4, with 0.02% sodium azide. |
Protein Storage
Storage: | Store it under sterile conditions at -70â? It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution: | A hard copy of COA with reconstitution instructions is sent along with the products. Please refer to it for more detailed information. |
Product Documents
COA is available upon request.
1. Xue, B., et al. (2016). "ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway." J Virol 90(15): 6832-6845.
2. Chen Y, Jiao B, Yao M, Shi X, Zheng Z, Li S, Chen L. ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis. Virus Res. 2017 Jan 2;227:231-239. doi: 10.1016/j.virusres.2016.10.013. Epub 2016 Oct 21. PMID: 27777077.
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